Guinea Pig Whole Blood
Cayman Chemical DocosahexaenoIc ACD ethyl S
An esterified form of DHA; increases plasma and erythrocyte membrane DHA levels in rats without altering arachidonic acid levels when administered in the diet to at a dose equivalent to 8 mg/kg of DHA; reduces the number of reference memory errors in an eight-arm radial maze in 100-week old rats at 300 mg/kg
Cayman Chemical 3 3SulfInyldIpropnoIc ACD
An APE1/Ref-1 inhibitor (IC50 = 40 µM); a building block in the synthesis of DSSO
Cayman Chemical Tannc Acd 25g
An inhibitor of the gastric H /K ATPase and an enantiomer of esomeprazole inhibits histamine-induced acid secretions in isolated rabbit gastric glands (IC50 781 UM) to a lesser extent than esomeprazole inhibits histamine-induced stomach acid secretion in rats at 30 mg/kg
Cayman Chemical PRfluorotetradecnoIc ACD 500mg
An antagonist of mGluR1 and mGluR2 selective for mGluR1 and mGluR2 over mGluR6 at 1 mM inhibits L-glutamate-induced increases in InsPs in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP in CHO cells expressing mGluR2 at 1 mM intraplantar administration reduces glutamate-induced paw licking in a mouse model of nociceptive pain at 1-10 nmol/paw
Cayman Chemical Tannc Acd 10g
An orally bioavailable selective inhibitor of PDGFRa PDGFRB and FLT3 (IC50s 11 3 2 and 4 nM respectively) also inhibits mutant forms of these kinases including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3 at nanomolar concentrations
Cayman Chemical Tannc Acd 5g
An a1-AR (IC50 3200 nM) and a2-AR antagonist (Kis 112 1230 354 and 173 nM for a2A a2B- a2C- and a2D-ARs respectively) inhibits a-AR agonist-induced contractions in isolated human corpus cavernosum smooth muscle (IC50 0 1 UM) lowers vascular resistance in norepinephrine-preconstricted IPPSFs (EC50 288 nM)